Design and Synthesis of 2-(5-ethyl-pyridine-2-yl) ethanol Analogs as Potential Microbial Agents

Navin B. Patel; Hemant R.Patel

doi:10.37285/ijddd.1.1.10

Articles

Vol. 1 No. 1 (2010): January-March 2010

Design and Synthesis of 2-(5-ethyl-pyridine-2-yl) ethanol Analogs as Potential Microbial Agents

Navin B. Patel ^▸^▾
Hemant R.Patel ^▸^▾

Requires Subscription or Fee pdf (INR 2000)

DOI: https://doi.org/10.37285/ijddd.1.1.10
Submitted: November 19, 2024
Published: 2024-11-19

Abstract

A novel series of chalcones and pyrimidines is described. The structures of the synthesized compounds were assigned on the basis of elemental analysis, IR, 1H NMR and 13C NMR spectral data. All the products were screened against different strains of bacteria and fungi. Most of these compounds showed better inhibitory activity in comparison to the standard drugs.

References

1. Abdel-Latif, N. A.; Sabry, N. M.; Mohamed, A. M.; Abdulla, M. M. Monatshefte fur Chemie. 2007, 138, 715.
2. Sabet , R.; Fassihi, A.; Moeinifard, B. Res. Pharma. Sci. 2007, 2, 103.
3. Vijey, A. M.; Shiny G.; Vaidhyalingam, V. ARKIVOC 2008, XI, 187.
4. Konshin, M. E.; Syropyatov, B. Y.; Efremov A. L.; Odegova T. F.; Vakhrin M. M. Pharm. Chem. J. 2008, 42, 387.
5. Acharya, B. N.; Thavaselvam D.; Kaushik M. P. Med. Chem. Res. 2008, 17, 487.
6. Shekarchia, M.; Pirali-Hamedania, M.; Navidpourb, L.; Adiba, N.; and Shafieeb,A. J. Iran. Chem. Soc. 2008, 5, 150.
7. Tomar, V.; Bhattacharjee, G.; Kamaluddina.; Kumar, A. Bioorg. & Med. Chem. Lett. 2007, 17, 5321.
8. Prasad, Y. R.; Kumar, P. R. D. Smiles, J.; Babu, P. A. ARKIVOC 2008, XI, 266.
9. Dominguez J. N.; Leon, C.; Rodrigues, J.; Dominguez ,
N. G.; Gut, J.; Rosenthal, P. J. II Farmaco 2005, 60, 307.
10. Mishra, N.; Arora, P.; Kumar, B.; Mishra L. C.; Bhattacharya, A.; Awasthi, S. K.; Bhasin, V. K. Eur. J. Med. Chem. 2008, 43, 1530.
11. Rani, P.; Srivastava, V. K.; Kumar, A. Eur. J. Med. Chem. 2004, 39, 449.
12. Jin, F.; Jin X. Y.; Jin, Y. L.; Sohn, D. W.; Kim, S. A.; Sohn, D. H.; Kim, Y. C. Kim, H. S. Arch. Pharm. Res. 2007, 30, 1359.
13. Kalirajan, R.; Sivakumar, S. U.; Jubie, S.; Gowramma, B.; Suresh, B. Int. J. Chem. Res. 2009, 1, 27.
14. Modzelewska, A.; Pettit, C.; Achanta, G.; Davidson, N. E.; Huang, P.; Khana, S. R. Bioorg.& Med. Chem. 2006, 14, 3491.
15. Cheng, J. H.; Hung, C. F.; Yang, S. C.; Wang, J. P.; Wond, S. J.; Lin, C. N. Bioorg. & Med. Chem. 2008, 16, 7270.
16. Gadhachanda, V.R.; Wu, B.; Wang, Z.; Kuhen, K.L.; Caldwell, J.; Zondler, H.; Walter, H.; Havenhandb, M.; Hea, Y. Bioorg. & Med. Chem. Lett. 2007, 17, 260.
17. Zhang, N.; Ayral-Kaloustian, S.; Nguyen, T.; Hernandez, R.; Lucas J.; Discafani, C.; Beyer C. Bioorg. & Med. Chem. 2009, 17, 111.
18. Xie, F.; Zhao, H.; Zhao, L.; Lou, L.; Hu Y. Bioorg. & Med. Chem. Lett. 2009, 18, 275.
19. Chhabria, M.T.; Bhatt, H.G.; Ravalc, H.G.; Ozac P.M. Bioorg. & Med. Chem. Lett. 2007, 17, 260.
20. Falcao, E.P.S.; Melo, S.J.; Srivastava, R.M.; Catanho, M.T.J.A.; Nascimento, S.C.D. Eur. J. Med. Chem. 2006, 41, 276.
21. Venu, T.D.; Khanum, S.A.; Firdouse, A.; Manuprasad,B. K., Sheena, S.; Mohamed, R.; Vishwanth B.S. Bioorg. & Med. Chem. Lett. 2008, 18, 4409.
22. Sunduru, N.; Nishi.; Palne, S.; Chauhan, P.M.S.; Gupta,S. Eur. J. Med. Chem. 2009, 44, 2473.
23. Rattan A., Antimicrobials in laboratory medicine, Churchill B I, Livingstone, New Delhi, 2000, 85.

Keywords

Pyridine
chalcone
pyrimidine
microbial studies

How to Cite

B. Patel , N., & R.Patel , H. (2024). Design and Synthesis of 2-(5-ethyl-pyridine-2-yl) ethanol Analogs as Potential Microbial Agents . International Journal of Drug Design and Discovery, 1(1). https://doi.org/10.37285/ijddd.1.1.10

Similar Articles

Amit Semwal, Amit Nigam, D.C.P Singh, Synthesis, Characterization and Biological Activity of Novel N-p-methylbenzoyl-N’ substituted thiourea , International Journal of Drug Design and Discovery: Vol. 2 No. 4 (2011): October-December 2011
Panneer Selvam T, Ramu P., Siva Kumar A, Synthesis, Characterization and Biological Activity of novel 3-benzyl-2- (4'-substituted phenyl)-4(5H)-(4''-nitrophenyl amino)-1, 3-oxazolidines , International Journal of Drug Design and Discovery: Vol. 2 No. 1 (2011): January – March 2011
Malleshappa N. Noolvi, Varun Bhardwaj, Harun M. Patel, 3D QSAR Studies on a Series of 4-Anilino Quinazoline Derivatives as Tyrosine Kinase (EGFR) Inhibitor: The k-Nearest Neighbor Molecular Field Analysis Approach , International Journal of Drug Design and Discovery: Vol. 1 No. 4 (2010): October-December 2010
Gomase V.S., Chitlange N.R., Microbial Proteomics Approach for Synthetic Vaccine Development form Bacillus Weihenstephanensis , International Journal of Drug Design and Discovery: Vol. 1 No. 4 (2010): October-December 2010
J.P. Sen, D.K. Shukla, A Jain, Conventional as well as Microwave Assisted Synthesis Characterization and Antimicrobial Studies of Some New Derivatives of -5-[2'-Marcapto-1-Methylene)-(1', 3’, 4’-Thiadiazoles)] - 1, 2, 3-Benzotriazoles , International Journal of Drug Design and Discovery: Vol. 1 No. 4 (2010): October-December 2010
Revathi Arun Gupta, Satish Gopalrao Kaskhedikar, Influence of Molecular Descriptors on Antimycobacterial Activity: A Chemometric Approach , International Journal of Drug Design and Discovery: Vol. 1 No. 4 (2010): October-December 2010
Sivakumar A, Arnold Emerson, Jayaraman G, Docking Studies on Transcription Factor sp1: The Transcriptional Down-Regulation of TACO Gene by EGCG and the Importance of TACO in M. tuberculosis Survival , International Journal of Drug Design and Discovery: Vol. 1 No. 3 (2010): July–September 2010
Bipul Bezbaruah, Pankaj Hazarika, Chitrani Medhi, The Binding of Acridine-4- Carboxamides within DNA Sequences: An Ab-initio and Force Field Studies , International Journal of Drug Design and Discovery: Vol. 1 No. 3 (2010): July–September 2010
Malleshappa N. Noolvi, Harun M. Patel, Navdeep Singh Sethi, 2D-QSAR Study of 1,3,4-thiadiazole-2-arylhydrazone Derivatives: An Approach to Design Antitrypanosomal Agents , International Journal of Drug Design and Discovery: Vol. 1 No. 3 (2010): July–September 2010
Debjani Banerjee, Yogeweswari Perumal, Anisha Thomas, Sriram Dharmarajan, Synthesis, In-vitro Evaluation and Computational Studies of Novel Isatinyl Derivatives for their Activity against HIV-TB Co-Infection , International Journal of Drug Design and Discovery: Vol. 1 No. 1 (2010): January-March 2010

<< < 1 2 3 > >>

You may also start an advanced similarity search for this article.

[1] 1. Abdel-Latif, N. A.; Sabry, N. M.; Mohamed, A. M.; Abdulla, M. M. Monatshefte fur Chemie. 2007, 138, 715.

[2] 2. Sabet , R.; Fassihi, A.; Moeinifard, B. Res. Pharma. Sci. 2007, 2, 103.

[3] 3. Vijey, A. M.; Shiny G.; Vaidhyalingam, V. ARKIVOC 2008, XI, 187.

[4] 4. Konshin, M. E.; Syropyatov, B. Y.; Efremov A. L.; Odegova T. F.; Vakhrin M. M. Pharm. Chem. J. 2008, 42, 387.

[5] 5. Acharya, B. N.; Thavaselvam D.; Kaushik M. P. Med. Chem. Res. 2008, 17, 487.

[6] 6. Shekarchia, M.; Pirali-Hamedania, M.; Navidpourb, L.; Adiba, N.; and Shafieeb,A. J. Iran. Chem. Soc. 2008, 5, 150.

[7] 7. Tomar, V.; Bhattacharjee, G.; Kamaluddina.; Kumar, A. Bioorg. & Med. Chem. Lett. 2007, 17, 5321.

[8] 8. Prasad, Y. R.; Kumar, P. R. D. Smiles, J.; Babu, P. A. ARKIVOC 2008, XI, 266.

[9] 9. Dominguez J. N.; Leon, C.; Rodrigues, J.; Dominguez ,

[10] N. G.; Gut, J.; Rosenthal, P. J. II Farmaco 2005, 60, 307.

[11] 10. Mishra, N.; Arora, P.; Kumar, B.; Mishra L. C.; Bhattacharya, A.; Awasthi, S. K.; Bhasin, V. K. Eur. J. Med. Chem. 2008, 43, 1530.

[12] 11. Rani, P.; Srivastava, V. K.; Kumar, A. Eur. J. Med. Chem. 2004, 39, 449.

[13] 12. Jin, F.; Jin X. Y.; Jin, Y. L.; Sohn, D. W.; Kim, S. A.; Sohn, D. H.; Kim, Y. C. Kim, H. S. Arch. Pharm. Res. 2007, 30, 1359.

[14] 13. Kalirajan, R.; Sivakumar, S. U.; Jubie, S.; Gowramma, B.; Suresh, B. Int. J. Chem. Res. 2009, 1, 27.

[15] 14. Modzelewska, A.; Pettit, C.; Achanta, G.; Davidson, N. E.; Huang, P.; Khana, S. R. Bioorg.& Med. Chem. 2006, 14, 3491.

[16] 15. Cheng, J. H.; Hung, C. F.; Yang, S. C.; Wang, J. P.; Wond, S. J.; Lin, C. N. Bioorg. & Med. Chem. 2008, 16, 7270.

[17] 16. Gadhachanda, V.R.; Wu, B.; Wang, Z.; Kuhen, K.L.; Caldwell, J.; Zondler, H.; Walter, H.; Havenhandb, M.; Hea, Y. Bioorg. & Med. Chem. Lett. 2007, 17, 260.

[18] 17. Zhang, N.; Ayral-Kaloustian, S.; Nguyen, T.; Hernandez, R.; Lucas J.; Discafani, C.; Beyer C. Bioorg. & Med. Chem. 2009, 17, 111.

[19] 18. Xie, F.; Zhao, H.; Zhao, L.; Lou, L.; Hu Y. Bioorg. & Med. Chem. Lett. 2009, 18, 275.

[20] 19. Chhabria, M.T.; Bhatt, H.G.; Ravalc, H.G.; Ozac P.M. Bioorg. & Med. Chem. Lett. 2007, 17, 260.

[21] 20. Falcao, E.P.S.; Melo, S.J.; Srivastava, R.M.; Catanho, M.T.J.A.; Nascimento, S.C.D. Eur. J. Med. Chem. 2006, 41, 276.

[22] 21. Venu, T.D.; Khanum, S.A.; Firdouse, A.; Manuprasad,B. K., Sheena, S.; Mohamed, R.; Vishwanth B.S. Bioorg. & Med. Chem. Lett. 2008, 18, 4409.

[23] 22. Sunduru, N.; Nishi.; Palne, S.; Chauhan, P.M.S.; Gupta,S. Eur. J. Med. Chem. 2009, 44, 2473.

[24] 23. Rattan A., Antimicrobials in laboratory medicine, Churchill B I, Livingstone, New Delhi, 2000, 85.