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Articles

Vol. 1 No. 4 (2010): October-December 2010

Microbial Proteomics Approach for Synthetic Vaccine Development form Bacillus Weihenstephanensis

DOI
https://doi.org/10.37285/ijddd.1.4.4
Submitted
November 25, 2024
Published
2024-11-28

Abstract

Bacillus weihenstephanensis causes systemic infections leading to be an obligatory step in infection. Peptide fragments of antigen protein can be used to select nonamers for use in rational vaccine design and to increase the understanding of roles of the immune system in infectious diseases. Analysis shows MHC class II binding peptides of antigen protein from Bacillus weihenstephanensis are important determinant for protection of host form bacteral infection. In this assay, we used PSSM and SVM algorithms for antigen design and predicted the binding affinity of bacterial protein having 210 amino acids, which shows 202 nonamers. Binding ability prediction of antigen peptides to major histocompatibility complex (MHC) class I & II molecules is important in vaccine development from Bacillus weihenstephanensis.

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