Design and Synthesis of 2-(5-ethyl-pyridine-2-yl) ethanol Analogs as Potential Microbial Agents

Navin B. Patel; Hemant R.Patel

doi:10.37285/ijddd.1.1.10

Articles

Vol. 1 No. 1 (2010): January-March 2010

Design and Synthesis of 2-(5-ethyl-pyridine-2-yl) ethanol Analogs as Potential Microbial Agents

Navin B. Patel ^▸^▾
Hemant R.Patel ^▸^▾

Requires Subscription or Fee pdf (INR 2000)

DOI: https://doi.org/10.37285/ijddd.1.1.10
Submitted: November 19, 2024
Published: 2024-11-19

Abstract

A novel series of chalcones and pyrimidines is described. The structures of the synthesized compounds were assigned on the basis of elemental analysis, IR, 1H NMR and 13C NMR spectral data. All the products were screened against different strains of bacteria and fungi. Most of these compounds showed better inhibitory activity in comparison to the standard drugs.

References

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Keywords

Pyridine
chalcone
pyrimidine
microbial studies

How to Cite

B. Patel , N., & R.Patel , H. (2024). Design and Synthesis of 2-(5-ethyl-pyridine-2-yl) ethanol Analogs as Potential Microbial Agents . International Journal of Drug Design and Discovery, 1(1). https://doi.org/10.37285/ijddd.1.1.10

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[1] 1. Abdel-Latif, N. A.; Sabry, N. M.; Mohamed, A. M.; Abdulla, M. M. Monatshefte fur Chemie. 2007, 138, 715.

[2] 2. Sabet , R.; Fassihi, A.; Moeinifard, B. Res. Pharma. Sci. 2007, 2, 103.

[3] 3. Vijey, A. M.; Shiny G.; Vaidhyalingam, V. ARKIVOC 2008, XI, 187.

[4] 4. Konshin, M. E.; Syropyatov, B. Y.; Efremov A. L.; Odegova T. F.; Vakhrin M. M. Pharm. Chem. J. 2008, 42, 387.

[5] 5. Acharya, B. N.; Thavaselvam D.; Kaushik M. P. Med. Chem. Res. 2008, 17, 487.

[6] 6. Shekarchia, M.; Pirali-Hamedania, M.; Navidpourb, L.; Adiba, N.; and Shafieeb,A. J. Iran. Chem. Soc. 2008, 5, 150.

[7] 7. Tomar, V.; Bhattacharjee, G.; Kamaluddina.; Kumar, A. Bioorg. & Med. Chem. Lett. 2007, 17, 5321.

[8] 8. Prasad, Y. R.; Kumar, P. R. D. Smiles, J.; Babu, P. A. ARKIVOC 2008, XI, 266.

[9] 9. Dominguez J. N.; Leon, C.; Rodrigues, J.; Dominguez ,

[10] N. G.; Gut, J.; Rosenthal, P. J. II Farmaco 2005, 60, 307.

[11] 10. Mishra, N.; Arora, P.; Kumar, B.; Mishra L. C.; Bhattacharya, A.; Awasthi, S. K.; Bhasin, V. K. Eur. J. Med. Chem. 2008, 43, 1530.

[12] 11. Rani, P.; Srivastava, V. K.; Kumar, A. Eur. J. Med. Chem. 2004, 39, 449.

[13] 12. Jin, F.; Jin X. Y.; Jin, Y. L.; Sohn, D. W.; Kim, S. A.; Sohn, D. H.; Kim, Y. C. Kim, H. S. Arch. Pharm. Res. 2007, 30, 1359.

[14] 13. Kalirajan, R.; Sivakumar, S. U.; Jubie, S.; Gowramma, B.; Suresh, B. Int. J. Chem. Res. 2009, 1, 27.

[15] 14. Modzelewska, A.; Pettit, C.; Achanta, G.; Davidson, N. E.; Huang, P.; Khana, S. R. Bioorg.& Med. Chem. 2006, 14, 3491.

[16] 15. Cheng, J. H.; Hung, C. F.; Yang, S. C.; Wang, J. P.; Wond, S. J.; Lin, C. N. Bioorg. & Med. Chem. 2008, 16, 7270.

[17] 16. Gadhachanda, V.R.; Wu, B.; Wang, Z.; Kuhen, K.L.; Caldwell, J.; Zondler, H.; Walter, H.; Havenhandb, M.; Hea, Y. Bioorg. & Med. Chem. Lett. 2007, 17, 260.

[18] 17. Zhang, N.; Ayral-Kaloustian, S.; Nguyen, T.; Hernandez, R.; Lucas J.; Discafani, C.; Beyer C. Bioorg. & Med. Chem. 2009, 17, 111.

[19] 18. Xie, F.; Zhao, H.; Zhao, L.; Lou, L.; Hu Y. Bioorg. & Med. Chem. Lett. 2009, 18, 275.

[20] 19. Chhabria, M.T.; Bhatt, H.G.; Ravalc, H.G.; Ozac P.M. Bioorg. & Med. Chem. Lett. 2007, 17, 260.

[21] 20. Falcao, E.P.S.; Melo, S.J.; Srivastava, R.M.; Catanho, M.T.J.A.; Nascimento, S.C.D. Eur. J. Med. Chem. 2006, 41, 276.

[22] 21. Venu, T.D.; Khanum, S.A.; Firdouse, A.; Manuprasad,B. K., Sheena, S.; Mohamed, R.; Vishwanth B.S. Bioorg. & Med. Chem. Lett. 2008, 18, 4409.

[23] 22. Sunduru, N.; Nishi.; Palne, S.; Chauhan, P.M.S.; Gupta,S. Eur. J. Med. Chem. 2009, 44, 2473.

[24] 23. Rattan A., Antimicrobials in laboratory medicine, Churchill B I, Livingstone, New Delhi, 2000, 85.