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Articles

Vol. 2 No. 4 (2011): October-December 2011

Synthesis, Characterization and Biological Activity of Novel N-p-methylbenzoyl-N’ substituted thiourea

Submitted
December 20, 2024
Published
2011-11-15

Abstract

A series of N-p-methylbenzoyl-N’ thiourea derivatives bearing different substituents have been synthesized and screened in order to evaluate for their antibacterial and antifungal activity. Antibacterial and antifungal activity of the title compounds has been evaluated by varying the substituents in the thiourea moiety. Reaction of p-methylbenzoyl chloride with ammonium thiocynate followed by the addition of various aromatic amines afforded N-p-methylbenzoyl-N’ substituted thiourea. The structures of newly synthesized compounds has been supported by IR and 1HNMR spectral analysis. Among the synthesized compounds N-(4-methylbenzoyl)-N’-(4-chloro-2-nitrophenyl) thiourea and N- (4-methylbenzoyl)-N’-(4-methylphenyl) thiourea have been found to exhibit excellent antibacterial and antifungal activity when compared with the standard drug.

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