Larvicidal Activity of Novel Organophosphorus Compounds against the Culex quinquefasciatus

Rajesh Kumar; Ajay Kumar Sharma; Arvind Kumar Gupta; Mahabir Parshad Kaushik

doi:10.37285/ijddd.1.3.1

Articles

Vol. 1 No. 3 (2010): July–September 2010

Larvicidal Activity of Novel Organophosphorus Compounds against the Culex quinquefasciatus

Rajesh Kumar^▸^▾
Ajay Kumar Sharma^▸^▾
Arvind Kumar Gupta^▸^▾
Mahabir Parshad Kaushik^▸^▾

Requires Subscription or Fee pdf (INR 2000)

DOI: https://doi.org/10.37285/ijddd.1.3.1
Submitted: November 24, 2024
Published: 2010-08-15

Abstract

Larvicidal activity of synthesized O,O-dipropyl (E)-2-(1-methyl-2-oxopropylidene) phosphorohydrazido thiolate (E) oxime and its analogues were studied against Culex quinquefasciatus. The synthesized compounds 1a-1r was first screened with three concentrations via 1, 10 and 100 ppm against 3rd or early 4th stage larvae of Culex quinquefasciatus. Then the active compounds 1d, 1o and 1p were further studied for their larvicidal activity with 4-6 concentrations ranging from 10-200 ppm. The LC50 , LC90 for the compound 1a, 1o and 1p were calculated by using statistical software Indostat 55.73, 46.60, 67.75 and 70.63, 155.16, 220.99 mg/l respectively.

References

[1] Chandre, E.; Darriet, I.; Darder, M.; Cuany, A.;Doannio, J.M.C.; Pasteur, N.; Gulliet, P. Med. Vet. Entomol. 1998 , 12, 359.
[2] Penilla, R.P.; Rodriguez, A.D.; Hemingway ,J.; Torres,J. L.; Arredondo-Jimenez, J.I.; Rodriguez, M. H. Med. Vet. Entomol. 1998, 12, 217.
[3] Rozendaal, J. A.; In Vector Control Geneva Switzerland; World Health Organization 1997; pp 5-177.
[4] Young, S. J.; Ju, H. J.; Hoi, S. L. J. Am. Mosq. Assoc. 2005, 21 (4), 400.
[5] NNDP/ World Bank/ WHO/ TDR and WHO/ UNICEF “Research on rapid geographical assessment of Bancroftian Filariasis” July 1997.
[6] Ben Cheikh, H.; Ben Ali-Haouas, Z.; Marquine, M.; Pasteur, N. J. Med. Entomol. 1998, 35, 251.
[7] Venkateswara Rao, J.; Desaiah, D.; Vig, P.J.S.; Venkateswarlu, Y. Toxicology 1998,129, 103.
[8] Venkateswarlu, Y.; Srinivasa Reddy, N.; Venkatesham, U. Novel bioactive compounds from the soft corals: chemistry and biomedical applications. In: Fingerman M, Nagabhushanam R (eds), Bio-organic Compounds: Chemistry and Biomedical Applications. Science Publishers, New Hampshire 2001; 6: 101-128.
[9] Proksch, P.; Edrada, R. A.; Ebel, R. Appl. Microbiol. Biotechnol. 2002, 59, 125.
[10] Donia, M.; Hamann, M. T. Lancet 2003, 3, 338.
[11] Haefner, B. Drug Discov. Today 2003, 8, 536.
[12] Jha, R. K.; Xu, Z. Mar. Drugs 2004, 2, 123.
[13] Gul, W.; Hamann, M. T. Life Sci. 2005, 78, 442.
[14] Mayer, A.M.S.; Hamann, M. T. Comp. Biochem. Phys. 2005,140, 265.
[15] Bisset, J.A.; Rodriguez, M.M.; Diaz, C.; Ortiz, E.; Marquetti, M. C.; Hemingway J. Bull. Entomol. Res. 1990, 80, 245.
[16] Kalyanasundaram, M.; Jambulingam, P.; Sahu, S. S.; Bhoopathi Doss, P. S.; Dominic Amalraj, D.; Das, P. K. Indian J. Med. Res. 2003, 117, 25.
[17] Worthing, C. R.; Walker, S. B. The pesticide manual - a world compendium, The British Crop Protection Council, 8th ed., Thornton Health 1987; pp 181-210.
[18] Nawrot-Modranka, J.; Nawrot, E.; Graczyk, J . Eur. J. Med. Chem. 2006, 41, 1301.
[19] (a) Kumar, R.; Gupta, A. K.; Kaushik, M. P. Molecules 2007, 12, 1334. (b) Kumar, R.; Gupta, A. K.; Kaushik, M.P. Molecules 2007, 12, 1632. (c) Kumar, R.; Gupta, A.K.; Kaushik, M. P. Molecules 2007, 12, 2193.
[20] Abbott, W.S.; J. Econ. Entomol. 1925, 18, 265.
[21] Finney, D. J. A statistical treatment of the sigmoid response curve, In: Probit analysis. Cambridge University Press, London, 1971; pp 333.

Keywords

Malaria
Culex quinquefasciatus
Larvicidal activity
O,O-dipropyl (E)-2-(1-methyl-2-oxopropylidene) phosphorohydrazido thiolate (E) oxime
statistical software Indostat

How to Cite

Kumar, R., Sharma, A. K., Gupta, A. K., & Kaushik, M. P. (2010). Larvicidal Activity of Novel Organophosphorus Compounds against the Culex quinquefasciatus. International Journal of Drug Design and Discovery, 1(3), 189–194. https://doi.org/10.37285/ijddd.1.3.1

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[1] [1] Chandre, E.; Darriet, I.; Darder, M.; Cuany, A.;Doannio, J.M.C.; Pasteur, N.; Gulliet, P. Med. Vet. Entomol. 1998 , 12, 359.

[2] [2] Penilla, R.P.; Rodriguez, A.D.; Hemingway ,J.; Torres,J. L.; Arredondo-Jimenez, J.I.; Rodriguez, M. H. Med. Vet. Entomol. 1998, 12, 217.

[3] [3] Rozendaal, J. A.; In Vector Control Geneva Switzerland; World Health Organization 1997; pp 5-177.

[4] [4] Young, S. J.; Ju, H. J.; Hoi, S. L. J. Am. Mosq. Assoc. 2005, 21 (4), 400.

[5] [5] NNDP/ World Bank/ WHO/ TDR and WHO/ UNICEF “Research on rapid geographical assessment of Bancroftian Filariasis” July 1997.

[6] [6] Ben Cheikh, H.; Ben Ali-Haouas, Z.; Marquine, M.; Pasteur, N. J. Med. Entomol. 1998, 35, 251.

[7] [7] Venkateswara Rao, J.; Desaiah, D.; Vig, P.J.S.; Venkateswarlu, Y. Toxicology 1998,129, 103.

[8] [8] Venkateswarlu, Y.; Srinivasa Reddy, N.; Venkatesham, U. Novel bioactive compounds from the soft corals: chemistry and biomedical applications. In: Fingerman M, Nagabhushanam R (eds), Bio-organic Compounds: Chemistry and Biomedical Applications. Science Publishers, New Hampshire 2001; 6: 101-128.

[9] [9] Proksch, P.; Edrada, R. A.; Ebel, R. Appl. Microbiol. Biotechnol. 2002, 59, 125.

[10] [10] Donia, M.; Hamann, M. T. Lancet 2003, 3, 338.

[11] [11] Haefner, B. Drug Discov. Today 2003, 8, 536.

[12] [12] Jha, R. K.; Xu, Z. Mar. Drugs 2004, 2, 123.

[13] [13] Gul, W.; Hamann, M. T. Life Sci. 2005, 78, 442.

[14] [14] Mayer, A.M.S.; Hamann, M. T. Comp. Biochem. Phys. 2005,140, 265.

[15] [15] Bisset, J.A.; Rodriguez, M.M.; Diaz, C.; Ortiz, E.; Marquetti, M. C.; Hemingway J. Bull. Entomol. Res. 1990, 80, 245.

[16] [16] Kalyanasundaram, M.; Jambulingam, P.; Sahu, S. S.; Bhoopathi Doss, P. S.; Dominic Amalraj, D.; Das, P. K. Indian J. Med. Res. 2003, 117, 25.

[17] [17] Worthing, C. R.; Walker, S. B. The pesticide manual - a world compendium, The British Crop Protection Council, 8th ed., Thornton Health 1987; pp 181-210.

[18] [18] Nawrot-Modranka, J.; Nawrot, E.; Graczyk, J . Eur. J. Med. Chem. 2006, 41, 1301.

[19] [19] (a) Kumar, R.; Gupta, A. K.; Kaushik, M. P. Molecules 2007, 12, 1334. (b) Kumar, R.; Gupta, A. K.; Kaushik, M.P. Molecules 2007, 12, 1632. (c) Kumar, R.; Gupta, A.K.; Kaushik, M. P. Molecules 2007, 12, 2193.

[20] [20] Abbott, W.S.; J. Econ. Entomol. 1925, 18, 265.

[21] [21] Finney, D. J. A statistical treatment of the sigmoid response curve, In: Probit analysis. Cambridge University Press, London, 1971; pp 333.