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Articles

Vol. 1 No. 3 (2010): July–September 2010

Antimicrobial Activities of some Newly Synthesized Indolylthiazolylazetidinone and Indolylthiazolylthiazolidinone Derivatives

Submitted
November 24, 2024
Published
2010-08-15

Abstract

Some heterocyclic schiff bases have been derived form the condensation of 5-methoxy-2-phenyl/methyl-3-(2-amino-1,3-thiazol-4-yl)indoles with different aromatic aldehydes have been synthesized. Then, these compounds were converted into novel azetidinones and thiazolidinones congeners. Compounds were evaluated for antibacterial and antifungal activities against various strains of bacterium and fungus, and substantial results were obtained. 5-methoxy-2-phenyl-3-[2'-(3''-chloro-2''-oxo-4''-(o-methoxyphenyl)-1''-azetidinyl)-1',3'-thiazol-4'-yl]indole was found to exhibit potential antibacterial (MIC 3.125˜g/ml) and antifungal (MIC 1.592-6.25 ˜g/ml) properties as compared to standard drugs against various pathogens.

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