A series of new indazolyl derivatives (1.1A - 1.5E) have been prepared from commercially available N-methyl-3-indazole carboxylic acid and 7-amino cephalosporic acid. The synthesized compounds were evaluated for anti-bacterial, analgesic and in vivo anti-inflammatory activities using acetic acid writhing in mice and carrageenan paw oedema method in mice. The series of compounds have analgesic activity in the order 1.4D>1.3C>1.5E>1.2B >1.1A Compound 1.3C had maximum zone of inhibition for Bacillus thurengensis, Staphylococus aureus, Bacillus Subtilis and showed least zone of inhibition to E. coli. It did not show any zone of inhibition to remaining bacteria. Compound 1.2B showed maximum zone of inhibition to Bacillus thurengensis and E. coli. Compound 1.1A showed maximum zone of inhibition Proteus vulgaris Bacillus Subtilis and Bacillus thurengensis
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