Synthesis and in vitro Biological Activity of Organic Charge-transfer  Complexes of lansoprazole, fluconazole, gabapentin and  gabalactum with Chloranilic and Picric Acids

Lingappa Mallesha; Kikkeri N. Mohana

doi:10.37285/ijddd.1.2.2

Articles

Vol. 1 No. 2 (2010): April– June 2010

Synthesis and in vitro Biological Activity of Organic Charge-transfer Complexes of lansoprazole, fluconazole, gabapentin and gabalactum with Chloranilic and Picric Acids

Lingappa Mallesha^▸^▾
Kikkeri N. Mohana^▸^▾

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DOI: https://doi.org/10.37285/ijddd.1.2.2
Submitted: November 19, 2024
Published: 2010-05-15

Abstract

Novel Charge-transfer (CT) complexes were synthesized in order to determine their antimicrobial and antioxidant activity relationships to improve the efficacy. The purity of the synthesized complexes was judged by their elemental analyses, and their chemical structures were confirmed by UV-visible, FT-IR and 1H NMR spectral studies. Among the synthesized compounds, 2a and 2b showed good antimicrobial activity. Compound 1a showed moderate antioxidant activity compared to standard drug by diphenylpicrylhydrazyl (DPPH) assay method.

References

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Keywords

Charge - transfer complexes
Fluconazole
Lansoprazole
Gabapentin
Antimicrobials
Antioxidant activity

How to Cite

Mallesha, L., & N. Mohana, K. (2010). Synthesis and in vitro Biological Activity of Organic Charge-transfer Complexes of lansoprazole, fluconazole, gabapentin and gabalactum with Chloranilic and Picric Acids . International Journal of Drug Design and Discovery, 1(2), 115–123. https://doi.org/10.37285/ijddd.1.2.2

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[1] [1] Koca, M.; Servi, S.; Kirilmis, C.; Ahmedzade, M.; Kazaz, C., Ozbek, B.; Otuk, G. Eur. J. Med. Chem. 2005, 40, 1351.

[2] [2] Ram, V. J. J. Heterocycl. Chem. 1988, 25, 253.

[3] [3] Halliwell, B. Biochem. Pharmacol. 1995, 49, 1341.

[4] [4] Vaya, J.; Aviram, M. Curr. Med. Chem. Immunol. Endocr. Metab. Agents 2001, 1, 99.

[5] [5] Amic, D.; Davidovic, D.; Beslo, D.; Trinajstic, N. Croat. Chem. Acta. 2003, 76, 55.

[6] [6] Middleton, E.; Kandaswami, C.; Theoharides, C. Pharmacol. Rev. 2000, 52, 673.

[7] [7] Pal, P.; Saha, A.; Mukherjee, A. K.; Mukherjee, D. C. Spectrochim. Acta A 2004, 60, 167.

[8] [8] (a) Saito, G.; Matsunaga, Y. Bull. Chem. Soc. 1974, 47, 1020. (b) Morukama, K. Acc. Chem. Res. 1977, 70, 294.(c) Kasha, M. Basic Life Sci. 1991, 58, 231.

[9] [9] Strohbusch, F.; Marshall, D.; Eyring, E. M. J. Phys. Chem. 1977, 82, 2447.

[10] [10] Matulis, V. E.; Lyakhov, A. S.; Gaponik, P.N.; Voitekhovich, S. V.; Ivashkevich, O. A. J. Mol. Structure. 2003, 649, 309.

[11] [11] Gaballa, A. S.; Wagner, C.; Teleb, S. M.; Nour, E. M.; Elmosallamy, M. A. F.; Kaluderovic, G. N.; Schmidt, H.; Steinborn, D. J. Mol. Structure 2008, 876, 301.

[12] [12] Bingham, Eula, Cohrssen, Barbara, Powell, Charles, H. Patty’s Toxicology; 5th ed., John Wiley and Sons: New York, 2001.

[13] [13] Iwahi, T.; Satoh, H.; Nakao, M.; Iwasaki, T.; Yamazaki, T.; Kubo, K.; Tamura, T.; Imada, A. Agents Chemother. 1991, 35, 490.

[14] [14] Biswas, S. K.; Yokoyama, K.; Kamei, K.; Nishimura, K.; Miyaji, M. Med. Mycol. 2001, 39, 283.

[15] [15] Fellemius, E.; Berglindh, T.; Sachs, G.; Elander, B.; Sjostrand, S. E.; Wallmark, B. Nature 1981, 290, 159.

[16] [16] Goodman, J. L.; Winston, D. J.; Greenfield, R. A.; Chandrasekar, P. H.; Fox, B.; Kaizer, H. N. Engl. J. Med. 1992, 326, 845.

[17] [17] Chadwick, D.W.; Anhut, H.; Greiner, M. J.; Alexander, J.; Murray, G. H.; Garofalo, E. A.; Pierce, M.W. Neurology 1998, 51, 1282.

[18] [18] Bowery, N.G. Annu. Rev. Pharmacol. Toxicol. 1993, 33, 109.

[19] [19] Rosenberg, J. M.; Harrell, C.; Ristic, H.; Werner, R. A.; Derosayro, A. M. Clin. J. Pain. 1997, 13, 251.

[20] [20] Placidi, F.; Mattia, D.; Romigi, A.; Bassetti, M. A.; Spanedda, F.; Marciani, M. G.; Placidi, F. Mattia, D.; Romigi, A.; Bassetti, M. A.; Spanedda, F.; Marciani, M.G. Clin. Neurophysiology 2000, 111, 1637.

[21] [21] Lima, J. M. L. Curr. Pharm. Des. 2000, 6, 873.

[22] [22] Morton, L. D.; Pellock, J. M. Curr .Pharm. Des. 2000, 6,

[23] [23] Gee, N. S.; Brown, J. P.; Dissanayake, V.U. K.; Offord, J.; Thurlow, R.; Woodruff, G.N. J. Biol. Chem. 1996, 271, 5768.

[24] [24] Hongqi Li, Yathirajan, H. S.; Mallesha, L.; Mohana, K. N.; Narayana, B. Acta Cryst. E 2009, 65, o783.

[25] [25] Anon, The Indian Pharmacopoeia, 3rd ed., 1996.

[26] [26] Khan, Z. K. In vitro and vivo screening techniques for bioactivity screening and evaluation, in: Proceedings of the international workshop UNIDO-CDRI, 1997; pp 943–946.

[27] [27] Mensor, L. L.; Menezes, F. S.; Leitao, G. G.; Reis, A. S.; Santos, T.C.; Coube, C. S.; Leitao, S. G. Phytother. Res. 2001, 15, 127.

Abstract

References

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