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Articles

Vol. 2 No. 1 (2011): January – March 2011

Synthesis and Pharmacological Evaluation of 7-{2-[4-(Substituted phenyl)-piperazin-1-yl]-2-Oxo-Ethoxy}-4-Methyl-Chromen-2-Ones as Serotonin 5-HT2 Receptors Antagonist

DOI
https://doi.org/10.37285/ijddd.2.1.9
Submitted
November 28, 2024
Published
2024-12-08

Abstract

Substitutedphenyl piperazines were treated with chloroacetylchloride to give respective 2-chloro-1-[4-(substitutedphenyl)-piperazin-1-yl]-ethanones which were subsequently coupled to 7-hydroxy-4-methyl-chromen-2-one to afford the target compounds 7-{2-[4-(substituted phenyl)-piperazin-1-yl]-2-oxo-ethoxy}-4-methyl-chromen-2-ones. The novel compounds were evaluated in-vivo for antagonism at serotonin 5-HT2 receptor. Some of the compounds synthesized showed high antagonistic activity for the target receptor. The binding affinity to these receptors depended greatly on the nature and position of substitution in phenyl ring.

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