Discovery of New Imidazolinones Derivatives as Potential Microbial Agents

Jitesh B Patel; Vikas A Desai

doi:10.37285/ijddd.2.1.6

Articles

Vol. 2 No. 1 (2011): January – March 2011

Discovery of New Imidazolinones Derivatives as Potential Microbial Agents

Jitesh B Patel^▸^▾
Vikas A Desai^▸^▾

Requires Subscription or Fee pdf (INR 2000)

DOI: https://doi.org/10.37285/ijddd.2.1.6
Submitted: November 28, 2024
Published: 2024-12-08

Abstract

A series of imidazolinone were prepared by heating the hippuric acid in presence of acetic anhydride and sodium acetate with different aromatic aldehydes gave 5-oxazolone derivatives which reacting with N-amino-2,3,4,5,6-pentafluoro benzamide in pyridine gave imidazolinone. All the synthesized compounds have been characterized on the basis of elemental analysis, IR, 1H-NMR and 13C-NMR spectral data. All the synthesized compounds have been screened against four different bacterial strains S. aureus, S. paratyphi-A, E. coli and B. subtilis and fungal strain F. molaniforme and A. niger. Some of the compound was endowed with a remarkable antibacterial as well as antifungal activity.

References

[1] De, B.; Gupta, J.; Saravanan, V.S.; Acta Pharm. 2005, 55, 287.
[2] Kadriye, B.; Karaburun, A.C.; Gundodu-Karaburun, N.; Demrayak, S.; Guven, K.; Arch Pharm. Res. 2003, 26, 773.
[3] Siddiqui, S.A.; Bhusare, S.R.; Jarikote, D.V.; Pawar,
R. P.; Vibhute, Y.B.; Bull. Korean Chem. Soc. 2001, 22, 1033.
[4] Ding, M.W.; Zeng, G.P.; Liu, Z.J.; Phosphorus, Sulfur and Silicon 2002, 177, 1315.
[5] Brzozowski, Z.; Kornicka, A.; Acta Pol. Pharm. 1999, 56,135.
[6] Jung, S.H.; Lee, H.S.; Song, J.S.; Kim, H.M.; Han, S.B.; Lee, C.W.; Lee, M.; Choi, D.R. Lee, J.A. Chung, Y.H.; Yoon, S.J.; Moon, E.; Hwang, H.S.; Seong, S.K.; Lee,
D. K.; Bioorg. Med. Chem. Lett. 1998, 8, 1547.
[7] Vogel A.L. A Text Book of Practical Organic Chemistry
E. LBS and Longmans Group and Co., London, 1971; pp 909.
[8] Rattan A.; Antimicrobials in laboratory medicine, Churchill B I, Livingstone, New Delhi, 2000; pp 85.

Keywords

Imidazolinone
Oxazolone
Antibacterial
Antifungal

How to Cite

Patel, J. B., & Desai, V. A. (2024). Discovery of New Imidazolinones Derivatives as Potential Microbial Agents. International Journal of Drug Design and Discovery, 2(1), 393–402. https://doi.org/10.37285/ijddd.2.1.6

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[1] [1] De, B.; Gupta, J.; Saravanan, V.S.; Acta Pharm. 2005, 55, 287.

[2] [2] Kadriye, B.; Karaburun, A.C.; Gundodu-Karaburun, N.; Demrayak, S.; Guven, K.; Arch Pharm. Res. 2003, 26, 773.

[3] [3] Siddiqui, S.A.; Bhusare, S.R.; Jarikote, D.V.; Pawar,

[4] R. P.; Vibhute, Y.B.; Bull. Korean Chem. Soc. 2001, 22, 1033.

[5] [4] Ding, M.W.; Zeng, G.P.; Liu, Z.J.; Phosphorus, Sulfur and Silicon 2002, 177, 1315.

[6] [5] Brzozowski, Z.; Kornicka, A.; Acta Pol. Pharm. 1999, 56,135.

[7] [6] Jung, S.H.; Lee, H.S.; Song, J.S.; Kim, H.M.; Han, S.B.; Lee, C.W.; Lee, M.; Choi, D.R. Lee, J.A. Chung, Y.H.; Yoon, S.J.; Moon, E.; Hwang, H.S.; Seong, S.K.; Lee,

[8] D. K.; Bioorg. Med. Chem. Lett. 1998, 8, 1547.

[9] [7] Vogel A.L. A Text Book of Practical Organic Chemistry

[10] E. LBS and Longmans Group and Co., London, 1971; pp 909.

[11] [8] Rattan A.; Antimicrobials in laboratory medicine, Churchill B I, Livingstone, New Delhi, 2000; pp 85.