Articles

Vol. 2 No. 3 (2011): July – September 2011

Synthesis, Characterization and Biological Evaluation of N [3-Chloro-2 (aryl)-4-oxoazitidin-1-y] pyridine-4-carboxamide

Sayyed Hussain^▸^▾
Shivaji Jadhav^▸^▾
Megha Rai^▸^▾
Mazahar Farooqui^▸^▾

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DOI: https://doi.org/10.37285/ijddd.2.3.3
Submitted: December 9, 2024
Published: 2024-12-09

Abstract

Isoniazid on addition with different aromatic aldehyde gives Schiff’s bases. The Schiff base so formed on treatment with chloroacetyl chloride and triethyl amine as a base catalyst in 1-4 Dioxan gives product 2a-2n.The synthesized compounds characterized by spectral analysis like IR, NMR & Mass and elemental analysis. The compounds were screened by anticonvulsant and antimycobacterial activity.

References

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Keywords

Isoniazid
Aromatic aldehyde (Ar-CHO) Azitidinone
base catalyst anticonvulsant
antimycobacterial activities

How to Cite

Hussain, S., Jadhav, S., Rai, M., & Farooqui, M. (2024). Synthesis, Characterization and Biological Evaluation of N [3-Chloro-2 (aryl)-4-oxoazitidin-1-y] pyridine-4-carboxamide. International Journal of Drug Design and Discovery, 2(3), 527–532. https://doi.org/10.37285/ijddd.2.3.3

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