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Articles

Vol. 1 No. 1 (2010): January-March 2010

Synthesis, Anti-Tuberculosis and Antiviral Activity of Novel 2-isonicotinoylhydrazono-5-arylidene-4-thiazolidinones

DOI
https://doi.org/10.37285/ijddd.1.1.3
Submitted
November 18, 2024
Published
2010-02-15

Abstract

This paper describes the synthesis and structural elucidation of some novel N'-[5-(substituted benzylidene)-3-alkyl-4-oxo-1,3-thiazolidin-2-ylidene]isonicotinohydrazides and evaluation of their chemotherapeutic potency. The most potent derivative demonstrated an IC90 value of 2.039 µg/ml and an IC50 value of 1.267 µg/ml against M. Tuberculosis H37Rv while one of our compounds inhibited cytopathicity of HIV-1 (IIIB) by 50% at 8.73 µg/ml and other two derivatives were found active against either thymidine kinase positive or deficient strains of varicella-zoster virus with IC50 values of 2.0 and 1.8 µg/ml.

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