5-one (10-14) and 1-[{2´-(2˝-substitutedaryl-4˝-thiazolidinon-3˝-yl)-1´,3´-thiazol-4´-yl}-amino-2-phenyl-4-cyclohexylideneimidazol]-5 one (15-19) have been synthesized from 1-[{2´-(substitutedarylidenylimino)-1´,3´-thiazol-4´-yl}-amino-2-phenyl-4-cyclohexylidene imidazol]-5-one (5-9). All these compounds of the present series have also been screened in vitro for their antibacterial activity against various strains of bacteria. Substantial results were obtained. Compound 11 showed superior antibacterial activity against Klebsiella pneumoniae ATCC 10031 with MIC 0.781 µg/ml. The structure of these compounds has been elucidated by IR, 1H-NMR, Mass spectral and elemental (C, H, N) analysis.
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