New Benzimidazolo Indane-1, 3-Dione Derivatives: Synthesis and In-vitro Screening Against Helminthic Infections

Jubie S; Gayathri R; Srividya A.R.; Kalirajan R; `Suresh S; Sankar S.; Elango K

doi:10.37285/ijddd.2.2.10

Articles

Vol. 2 No. 2 (2011): April – June 2011

New Benzimidazolo Indane-1, 3-Dione Derivatives: Synthesis and In-vitro Screening Against Helminthic Infections

Jubie S^▸^▾
Gayathri R^▸^▾
Srividya A.R.^▸^▾
Kalirajan R^▸^▾
`Suresh S^▸^▾
Sankar S.^▸^▾
Elango K^▸^▾

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DOI: https://doi.org/10.37285/ijddd.2.2.10
Submitted: November 28, 2024
Published: 2024-12-08

Abstract

Novel benzimidazolo indane-1, 3-dione derivatives were synthesized and characterized by IR, 1HNMR and Mass spectral analysis. Biological screening of synthesized compounds allowed the identification of some novel anthelmintic agents bearing indane-1, 3-dione and benzimidazole scaffolds. Some of these compounds exhibited promising anthelmintic activities.

References

[1] Jubie, S.; Meena, S.; Ramseshu, K.V.; Jawahar, N.; Vijayakumar.; Ind J Chem. 2010, 49 B, 1261.
[2] Roberto, H.; Belen, B.; Fructuoso, B.; Avelino, M.; Tetrahedron Lett. 2007, 47, 6437.
[3] Meena, S.; Shankar, D.; Ramseshu, K.V.; Giles, D.; Ind J Chem. 2006, 45 B, 1572.
[4] Giles, D.; Prakash, M.S.; Ramseshu, K.V.; E J Chem. 2007, 4,328.
[5] Akbar, M. ; Naser, M. ; Mansourch, M. J Heterocycl Chem. 2010, 47, 77.
[6] Ashutosh, K.B.; Hasanali, K.P.R.S.; Manish P.P.; H.D.P. Indian J heterocycl Chem. 2003, 13, 187.
[7] Ajaiyeoba, E.O.; Onocha, P.A.; Olarenwaju, O.T.; Pharm Bio. 2001, 39, 217.
[8] Satish, B.K.; Ravindra, A.F.; Int J Pharm Tech Res. 2009,1,68.

Keywords

Indane-1,3-Dione
1,3-Dioxe-1,2,3-trihydro Indane 6-sulphonyl benzimidazole derivatives
electrophilic substitution
anthelmintic activity

How to Cite

S, J., R, G., A.R., S., R, K., S, `Suresh, S., S., & K, E. (2024). New Benzimidazolo Indane-1, 3-Dione Derivatives: Synthesis and In-vitro Screening Against Helminthic Infections . International Journal of Drug Design and Discovery, 2(2), 506–509. https://doi.org/10.37285/ijddd.2.2.10

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[1] [1] Jubie, S.; Meena, S.; Ramseshu, K.V.; Jawahar, N.; Vijayakumar.; Ind J Chem. 2010, 49 B, 1261.

[2] [2] Roberto, H.; Belen, B.; Fructuoso, B.; Avelino, M.; Tetrahedron Lett. 2007, 47, 6437.

[3] [3] Meena, S.; Shankar, D.; Ramseshu, K.V.; Giles, D.; Ind J Chem. 2006, 45 B, 1572.

[4] [4] Giles, D.; Prakash, M.S.; Ramseshu, K.V.; E J Chem. 2007, 4,328.

[5] [5] Akbar, M. ; Naser, M. ; Mansourch, M. J Heterocycl Chem. 2010, 47, 77.

[6] [6] Ashutosh, K.B.; Hasanali, K.P.R.S.; Manish P.P.; H.D.P. Indian J heterocycl Chem. 2003, 13, 187.

[7] [7] Ajaiyeoba, E.O.; Onocha, P.A.; Olarenwaju, O.T.; Pharm Bio. 2001, 39, 217.

[8] [8] Satish, B.K.; Ravindra, A.F.; Int J Pharm Tech Res. 2009,1,68.