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Articles

Vol. 2 No. 1 (2011): January – March 2011

Investigation of 1, 3, 4-Oxadiazole Scaffold as Potentially Active Compounds

DOI
https://doi.org/10.37285/ijddd.2.1.1
Submitted
November 28, 2024
Published
2011-02-15

Abstract

In the present work, various Schiff’s bases of isoniazid bearing 1, 3, 4-oxadiazole nucleus were synthesized. These compounds were purified, characterized and evaluated in vitro for antibacterial, antifungal and antiviral activities. Compound 5 showed better biological profile.

References

  1. [1] (a) Frank, P.V.; Girish, K.S.; Kalluraya, B. J. Chem. Sci., 2007, 119, 41. (b) Kadi, A.A.; El-Brollosy, N.R.; Al-Deeb, O.A.; Habib, E.E.; Ibrahim, T.M.; El-Emam, A.A. Eur. J. Med. Chem., 2007, 42, 235.
  2. [2] (a) Somani, R.R.; Shirodkar, P.Y.; Kadam, V.J. Lett. Drug Desi. Disco., 2008, 5, 348.(b) Ouyang, X.; Patnitski, E. etal. Bioorg. Med. Chem. Lett., 2006, 16, 1191.
  3. [3] Bhandari, S. .; Bothara, K.G.; Raut, M.K.; Patil, A.A.; Sarkate, A.P.; Mokale, V.J. Bioorg. Med. Chem., 2008, 16, 1822.
  4. [4] Kucukguzel, S.G.; Kucukguzel, I.; Tatar, E.; Rollas, S.; Sahin, F.; Gulluce, M.; De Clercq, E.; Kabasakal, L. Eur.
  5. J. Med. Chem., 2007, 42, 893.
  6. [5] Muhammad, Z.; Rashid, I.; Najim, A.A.; Javid, H. Z.; Muhammad, A. ChemInform, 2007, 38, Published Online.
  7. [6] Kim, R.M.; Rouse, E.A.; Chapman, K.T.; Schleif, W.A.; Olsen, D.B.; Stahlhut, M.; Rutkowski, C.A.; Emini, E.A.; Tata, J.R. Bioorg. Med. Chem. Lett., 2004, 14, 4651.
  8. [7] Navarrete-Vazquez, G.; Molina-Salinas, G.M.; Duarte-Fajardo, Z.V.; Vargas-Villarreal, J.; Estrada-Soto, S.; Gonzalez-Salazar, F.; Hernandez-Nunez, E.; Said-Fernandez, S. Bioorg. Med. Chem. Lett., 2007, 15, 5502.
  9. [8] Kiselyov, A.S.; Semenova, M.; Semenov, V.V.; Milligan,
  10. D. Bioorg. Med. Chem. Lett., 2006, 16, 1913.
  11. [9] Khan, M.T.H.; Choudhary, M.I.; Khan, K.M.; Rani, M.; Rahman, A. Bioorg. Med. Chem., 2005, 13, 3385.
  12. [10] Xiaohu, O.; Piatnitski, E.; Pattaropong, V.; Xiaoling, C., Hai-Ying, He.; etal. Bioorg. Med. Chem. Lett., 2006, 16, 1191.
  13. [11] Hu, G. Q.; etal. Chinese Chem. Lett., 2006, 17, 19.
  14. [12] Hearn, M.J.; Cynamon, M.H. J. Antimicro. Chemothe., 2004, 53, 185.
  15. [13] Somani R.R.; Agrawal A.G.; Bhanushali, U.V.; Kalantri
  16. P. P.; Clercq, E. D. Int. J. Drug Des. & Discov. 2010, in press.
  17. [14] Sheban, M. A. E. Adv. Heterocycl. Chem., 1998, 70, 163.
  18. [15] Gervay, J.; Flaherrty, T.M.; Holmes, D. Tetrahedron, 1997, 53, 16355.
  19. [16] El Ashry, E.; El Kilany, Y. H. Adv. Heterocycl. Chem., 1998, 69, 129.
  20. [17] Mohd, A.; Kumar, S. Eur. J. Med. Chem., 2004, 39, 535.
  21. [18] Liu, K. Ch.; Hu, M.K.; Arch. Pharm., 1987, 320(2), 166; Chem. Abstr. 1987, 107,198229 a.
  22. [19] Asati, K.C.; Srivastava, S.K.; Srivastava, S.D. Ind. J. Chem., 2006, 45B, 526.
  23. [20] Kidwai, M.; Kumar, P.; Goel, Y.; Kumar, K. Ind. J. Chem. 1997, 36B, 175.
  24. [21] Kucukguzel, S.G.; Mazi, A.; Sahin, F.; Ozturk, S.; Stables, J. P. Eur. J. Med. Chem., 2003, 38, 1005.
  25. [22] El-Khawass, S.M.; Habib, N.S. J. Heterocyclic. Chem., 1989, 26, 177.
  26. [23] Bedia, K.; Elcin, O.; Seda, U.; Fatma, K.; Nathlay, S.; Sevim, R.; Dimalgo, A. Eur. J. Med. Chem., 2006, 41, 1253.
  27. [24] Taoa, J.; Caoab, L.; Wanga, C.; Wanga, D. J. Chin. Chem. Soc., 2006, 53(5), 1193.
  28. [25] El-Essawy F.A.; Khattab, A.F.; Abdel-Rahman, A. Monatshefte fur Chemie, 2007, 138, 777.
  29. [26] Pauwels, R.; Balzarini, J.; Baba, M.; Snoeck, R.; Clercq,E. D. J. Virol.Methods, 1988, 20, 309.

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