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Articles

Vol. 1 No. 3 (2010): July–September 2010

Cupric Chloride Catalysed Synthesis of 5-methylmercaptothiocarbonyl-4-aryl-3,4-dihydropyrimidin-2(1H)-ones under Solvent-free Condition and their Antimicrobial Activities

Submitted
November 24, 2024
Published
2010-08-15

Abstract

Copper (II) chloride in the absence of any solvent, efficiently catalyses the synthesis of 5-methyl mercaptothiocarbonyl-4-aryl-3,4-dihydropyrimidin-2(1H)-ones (80–87% yields) by the Biginelli reaction. Six pure compounds were selected and examined their antifungal activities against the radial growth of two fungal species Curvularia oryzae and Fusarium moniliforme using Poison food technique and antibacterial activities against two bacteria viz. Bacillus cereus and Bacillus amyloliquefaceins using Agar well diffusion method.

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