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Articles

Vol. 1 No. 2 (2010): April– June 2010

PPARγ- Novel Target in Antidiabetic Drug Design

DOI
https://doi.org/10.37285/ijddd.1.2.7
Submitted
November 24, 2024
Published
2010-05-15

Abstract

The nuclear receptors constitute one of the largest groups of transcription factors known today. The peroxisome proliferator-activated receptors (PPAR) are members of the nuclear receptor supergene family and are considered as key sensors of both lipid and glucose homeostasis. The role of the PPAR γ isoform in glucose metabolism is illustrated by the fact that antidiabetic thiazolidinediones have been shown to be bonafide PPARγ ligands. The present review has established the PPARs as molecular target for the design and development of antidiabetic drugs.

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