The 2-phenyl-benzoxazin-4-ones were condensed with primary amine to form the 2,3-disubstituted quinazolin-4(3H)-ones. Their chemical structure was elucidated by means of spectral (FT-IR, 1H-NMR, MS) and elemental analysis. All compounds exhibited some activity against herpes simplex virus type 1 (IC50's = 20 – 30 µM). Certain compounds had modest activity (IC50 = 20-60 µM) against vaccinia and/or cowpox virus, similar to cidofovir. Weak to no activity was observed against human cytomegalovirus. With one exception little cytotoxicity was observed at concentrations up to 100 µM thereby suggesting the possibility of a virus-specific mechanism of action.
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