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Articles

Vol. 1 No. 2 (2010): April– June 2010

Synthesis and Biological Activities of N’-[4-(substituted benzylideneamino)-3- (2′,4′-dichlorophenoxymethyl)-1,2,4-triazol-5yl)] isonicotinyl hydrazides

DOI
https://doi.org/10.37285/ijddd.1.2.1
Submitted
November 19, 2024
Published
2010-05-15

Abstract

N'-[4-(substituted benzylideneamino)-3-(2′,4′-dichlorophenoxymethyl)-1,2,4-triazol-5yl)] isonicotinyl hydrazide derivatives have been synthesized by the reaction between N′ -[4-amino-3-(2′,4′-dichlorophenoxymethyl)-1,2,4-triazol-5yl] isonicotinyl hydrazide and various aromatic aldehydes in presence catalytic amount of hydrochloric acid in alcohol. All these compounds were screened for antibacterial, antifungal and antitubercular activity. The compounds 3b and 3j exhibited more potent antifungal activity against A. niger, and A. fumigatus at MIC of 0.25 µg/mL.

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