Skip to main navigation menu Skip to main content Skip to site footer
##common.pageHeaderLogo.altText##

Articles

Vol. 1 No. 2 (2010): April– June 2010

Synthesis and Biological Activities of N’-[4-(substituted benzylideneamino)-3- (2′,4′-dichlorophenoxymethyl)-1,2,4-triazol-5yl)] isonicotinyl hydrazides

DOI
https://doi.org/10.37285/ijddd.1.2.1
Submitted
November 19, 2024
Published
2010-05-15

Abstract

N'-[4-(substituted benzylideneamino)-3-(2′,4′-dichlorophenoxymethyl)-1,2,4-triazol-5yl)] isonicotinyl hydrazide derivatives have been synthesized by the reaction between N′ -[4-amino-3-(2′,4′-dichlorophenoxymethyl)-1,2,4-triazol-5yl] isonicotinyl hydrazide and various aromatic aldehydes in presence catalytic amount of hydrochloric acid in alcohol. All these compounds were screened for antibacterial, antifungal and antitubercular activity. The compounds 3b and 3j exhibited more potent antifungal activity against A. niger, and A. fumigatus at MIC of 0.25 µg/mL.

References

  1. [1] Olcay, B.; Hakan, B. Molecules. 2006, 11, 469-477.
  2. [2] Rattan, A.; Kalia, A.; Ahmad, N. Emerg. Infect. Dis. 1998, 4, 195-196.
  3. [3] Demirbas, A.; Deniz, S.; Demirbas, N.; Sengül, A.
  4. K. Eur. J. Med. Chem. 2009, 44(7), 2896-2903.
  5. [4] Olcay, B.; Bahittin, K.; Murat, K. Turk. J. Chem. 2006, 30, 29- 40.
  6. [5] Francis, G.; Cedric, L.; Fabrice, P.; Damien, C.; Patrice, L.; Marc Le, B. Bioorg. Med. Chem. Lett. 2008, 18, 1820-1824.
  7. [6] Desai, N. C.; Shukla, H.K.; Thaker, K. A. J. Ind. Chem. Soc. 1984, 61, 239-241.
  8. [7] Iraj, R. ; Charalabou, C.; Panagiotis, Z.; Athina, G.; Marina, S.; Jasmina, G. Bioorg. Med. Chem. 2008, 16, 116-1161.
  9. [8] Kucukguzel, I.; Esra, T.; Kucukguzel, S.G.; Rollas, S.; DeClercq E. Eur. J. Med. Chem. 2008, 43(2),381- 392.
  10. [9] Mahendra, R. S.; Kiran, K. M.; Hanimi, R. G.; Tatikonda, S.; Chakravarthy, A. K.; Dolly, P. Bioorg. Med. Chem. 2007, 15, 3997- 4008.
  11. [10] Upadhayaya, R. S.; Sinha, N.; Jain, S.; Kishore, N.; Chandra, R.; Arora, S. K. Bioorg. Med. Chem. 2004, 12, 2225-2228.
  12. [11] Latifeh, N.; Hamed, S.; Khosrou, A.; Mohsen, A.; Mohammad, H.; Ghahremani, R. Bioorg. Med. Chem. 2006, 14, 2507-2517.
  13. [12] Yasemin, D.; Bilge, C.; Esra, K.; Fethi, S.; Ningur,
  14. N. Turk. J. Chem. 2007, 31, 1- 13.
  15. [13] Almarirad, A. Bioorg. Med. Chem. Lett. 2004, 14, 6057-6059.
  16. [14] Ronad, P. M.; Satyanarayana, D.; Hunashal, R. D.; Maddi, V. S.; Arch.Pharm.Chem.Life Sci. 2008, 341, 696-700.
  17. [15] Maddi, V.; Raghu, K. S.; Rao, M. N. A. J. Pharm. Sci. 1992, 81, 964-966.
  18. [16] CLSI / NCCLS guidelines. Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria that grow aerobically; Approved Standard; 7th Ed., 2006.
  19. [17] Lingappa, B.; Girisha, K. S.; Kalluraya, B.; Rai, N. S.; Kumari, N. S. Ind. J.Chem. 2008, 47B, 1858-1864.
  20. [18] Udupi, R.H.; Rajeeva, B.; Srinivasulu, N.; Bhat, A.R. Ind J. Heterocycl. Chem. 2004, 13, 233-236.
  21. [19] Refat, E. S. Indian J. Chem. 2006, 45B, 738-746.
  22. [20] Murry, P. R.; Baron, E. J.; Pfaller, M.A.; Tenover,F. C.; Yolken R. H. Am. Soc. Microbiol.; Woods, G. L., Ed.; Washington Press: Washington, DC, USA, 1995.
  23. [21] McFarland, J. J. Am. Med. Assoc. 1907, 14, 1176-1178.
  24. [22] Yajko, D. M.; Madej, J. J.; Lacaster, M. V.; Sanders, C. A.; Cawthon, V. L.; Gee, B.Clin. Microbiol. 1995, 33, 2324-2325.

Similar Articles

1 2 3 4 5 6 7 > >> 

You may also start an advanced similarity search for this article.