Suzuki coupling on 4-(3-bromobenzylidene)-3-methyl-  1-phenyl-1H-pyrazol-5(4H)-one

Rishikesh Vilas Antre; Cendilkumar A; Rajagopal Nagarajan

Articles

Vol. 2 No. 4 (2011): October-December 2011

Suzuki coupling on 4-(3-bromobenzylidene)-3-methyl- 1-phenyl-1H-pyrazol-5(4H)-one

Rishikesh Vilas Antre^▸^▾
Cendilkumar A^▸^▾
Rajagopal Nagarajan^▸^▾

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Submitted: December 20, 2024
Published: 2011-11-15

Abstract

Reaction of 4-(3-bromobenzylidene)-3-methyl-1-phenyl-1H-pyrazol-5(4H)-one with phenylboronic acid by using Pd(PPh3)4 as a catalyst in presence of K2CO3 and DMF gives the formation of 4-(3-phenylbenzylidene) -3-methyl-1-phenyl-1H-pyrazol-5(4H)-one. Detailed spectroscopic data (IR, 1H NMR, 13C NMR, MS, CHN) are presented.

References

[1] Brana, M.F.; Gradillas, A.; Ovalles, A.G.; Lopez, B.; Acero, N.; Llinaresc F.; Mingarroa D.M. Bioorg. Med. Chem. 2008, 14, 9.
[2] Souza, F.R.; Souza, V.T.; Ratzlaff, V.; Borges, L.P.; Oliveira, M.R.; Bonacorso, H.G. Eur. J. Pharmacol. 2002, 451, 141.
[3] El-Hawash, A.M.; El-Sayed, A.M.B.; El-Ashmawey I.M. Eur. J. Med. Chem. 2006, 41, 155.
[4] Basilio, M. J. Pharm. Biomed. Anal. 2003, 33, 423.
[5] Mohd, A.; Kumar, S. Indian J. Chem. 2005, 44(B), 2532.
[6] Bondock, S.; Rabie, R.; Etman, H.A.; Fadda, A.A. Eur. J. Med. Chem. 2008, 43(10), 2122.
[7] Castagnolo, D.; Manetti, F.; Radi, M.; Bechi, B.; Pagano, M.; Logu, A.D.; Meleddu, R.; Saddi, M.; Botta, M. Bioorg. Med. Chem. 2009, 17, 5716.
[8] Kimata, A.; Nakagawa, H.; Ohyama, R.; Fukuuchi, T.; Ohta, S.; Suzuki, T.; Miyata. N. J. Med. Chem. 2007, 50, 5053.
[9] Antre, R. V.; Cendilkumar, A.; Goli, D.; Andhale, G. S.; Oswal, R. J. Saudi Pharma. J. (Article in press)
[10] Sharma, C.; Thadhaney, B.; Pemawat G.; Talesara G.L.; Indian J. Chem. 2008, 47B, 1892.
[11] Ma, R.; Zhu, J.; Liu, J.; Chen, L.; Shen, X.; Jiang, H.; Li, J.; Molecules 2010, 15, 3593.

Keywords

Suzuki coupling
pyrazolone

How to Cite

Antre, R. V., A, C., & Nagarajan, R. (2011). Suzuki coupling on 4-(3-bromobenzylidene)-3-methyl- 1-phenyl-1H-pyrazol-5(4H)-one. International Journal of Drug Design and Discovery, 2(4), 674–675. Retrieved from https://ijddd.com/index.php/ijddd/article/view/91

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[1] [1] Brana, M.F.; Gradillas, A.; Ovalles, A.G.; Lopez, B.; Acero, N.; Llinaresc F.; Mingarroa D.M. Bioorg. Med. Chem. 2008, 14, 9.

[2] [2] Souza, F.R.; Souza, V.T.; Ratzlaff, V.; Borges, L.P.; Oliveira, M.R.; Bonacorso, H.G. Eur. J. Pharmacol. 2002, 451, 141.

[3] [3] El-Hawash, A.M.; El-Sayed, A.M.B.; El-Ashmawey I.M. Eur. J. Med. Chem. 2006, 41, 155.

[4] [4] Basilio, M. J. Pharm. Biomed. Anal. 2003, 33, 423.

[5] [5] Mohd, A.; Kumar, S. Indian J. Chem. 2005, 44(B), 2532.

[6] [6] Bondock, S.; Rabie, R.; Etman, H.A.; Fadda, A.A. Eur. J. Med. Chem. 2008, 43(10), 2122.

[7] [7] Castagnolo, D.; Manetti, F.; Radi, M.; Bechi, B.; Pagano, M.; Logu, A.D.; Meleddu, R.; Saddi, M.; Botta, M. Bioorg. Med. Chem. 2009, 17, 5716.

[8] [8] Kimata, A.; Nakagawa, H.; Ohyama, R.; Fukuuchi, T.; Ohta, S.; Suzuki, T.; Miyata. N. J. Med. Chem. 2007, 50, 5053.

[9] [9] Antre, R. V.; Cendilkumar, A.; Goli, D.; Andhale, G. S.; Oswal, R. J. Saudi Pharma. J. (Article in press)

[10] [10] Sharma, C.; Thadhaney, B.; Pemawat G.; Talesara G.L.; Indian J. Chem. 2008, 47B, 1892.

[11] [11] Ma, R.; Zhu, J.; Liu, J.; Chen, L.; Shen, X.; Jiang, H.; Li, J.; Molecules 2010, 15, 3593.