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Articles

Vol. 2 No. 2 (2011): April – June 2011

Microwave Assisted Synthesis and Evaluation of Thiazole Derivatives as M. tuberculosis and Antimicrobial Activity

DOI
https://doi.org/10.37285/ijddd.2.2.5
Submitted
November 28, 2024
Published
2024-12-08

Abstract

In last few decades, though significant progress has been made in the treatment and control strategies of tubercular infections by introducing new diagnostic and monitoring tools and combination therapy, it still continues to be severe problem. Thus with the aim of developing novel molecule with improved potency for treating Mycobacterium tuberculosis H37Rv strain infections and with decreased probability of developing drug resistance, herein we report the synthesis of thiazole derivatives, starting from ethyl acetoacetate, by microwave organic reaction enhancement method (MORE) and results of investigations of their antimycobacterial and antimicrobial activities. Many compounds have shown promising activity while others were inactive.

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