Skip to main navigation menu Skip to main content Skip to site footer
##common.pageHeaderLogo.altText##

Articles

Vol. 2 No. 2 (2011): April – June 2011

Synthesis and Pharmacological Evaluation of 3-alkyl/aryl–2- methylquinazolin-4-one Derivatives

DOI
https://doi.org/10.37285/ijddd.2.2.3
Submitted
November 28, 2024
Published
2024-12-08

Abstract

Quinazolin-4-ones with 2, 3-disubstitution is reported to possess significant analgesic, anti-inflammatory and anticonvulsant activities. We have developed an efficient method for the synthesis of 3-substituted-2-methylquinazolin-4-one by the condensation reaction of Anthranilic acid, acetic anhydride with various amines. The synthesized compounds were evaluated for anxiolytic activity by Elevated plus Maze Test and Light and Dark Test. It is observed that the aliphatic and aromatic substitution at 3-position of 2-methylquinazolin-4-one gives potent anxiolytic activity. In particular, ENA showed highest anxiolytic activity in Elevated plus Maze Test and EMQ and AMQ showed highest anxiolytic activity in Light and dark test model

References

  1. [1] Gabriel Ber, 36, 1903,800.
  2. [2] The chemistry of recently isolated naturally occurring quinazolinone alkaloids Tetrahedron report number 771, Division of Organic Chemistry (Synthesis), National Chemical Laboratory.
  3. [3] Reddy, P.S.; Reddy, P.P.; Vasantha T. Heterocycles, 2003, 60,183.
  4. [4] El-Hiti, G.A.; Heterocycles, 2000, 53, 1839.
  5. [5] El-Hiti, G.A.; Abdel-Megeed, M.F.; Heterocycles, 2005,65,3007.
  6. [6] Alagarsamy, V.; Revathi, R.; Vijay Kumar, S.; Ramseshu,K. V.; Pharmazie, 2003,58,4.
  7. [7] Alagarsamy, V.; Thangathirupathy, A.; Mandal, S.C.; Rajasekaran, S.; Vijay Kumar, S.; Revathi, RIndian J Pharm Sci, 2006,68,108.
  8. [8] Bhalla, M.; Srivatava, V.K.; Bhalla, T.N.; Shanker, K.; Arzneimittelforschung, 1993,43,595.
  9. [9] Zappala, M. ; Grasso, S. ; Micale, N. ; Zuccala, G. ; Menniti, F.S.; Ferreri, G. Bioorg Med Chem Lett 2003,13,4427.
  10. [10] Chao, Q.; Deng, L.; Shih, H.; Leoni, L.M.; Genini, D.; Carson, D.A J. Med. Chem., 1999,42,3860.
  11. [11] Alagarsamy, V.; Muthukumar, V.; Pavalarani, N.; Vasanthanathan, P.; Revathi, R Biol. Pharm. Bull., 2003,26,557.
  12. [12] http://www.ohanxiety.com/anxiery-resource/74-psychological-biological-theories.
  13. [13] McLaughlin, K.; Behar, E.; Borkovec, T Journal of Clinical Psychology, 2005,64, 905–918.
  14. [14] Kessler.K, Arch. Gen. Psychiatry, 2005,62(6), 617.

Similar Articles

<< < 1 2 3 4 5 6 7 > >> 

You may also start an advanced similarity search for this article.